Solgar Inositol 500 mg Vegetable Capsules - Vitamin B8 - Vegan, Vegetarian, Kosher, 50 Count (Pack of 1)

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The most robust effect of supplementation with inositol is on blood glucose control, [7] [8] [9] [10] [11] and this effect may be explained by inositol’s role in insulin signaling and its ability to increase insulin sensitivity. All of these values translate to an improvement of metabolic syndrome as well as a decreased risk of cardiovascular disease. Meta-analyses show that supplementation with inositol during pregnancy might reduce the incidence of gestational diabetes and related birth complications. Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial.

At the end of the treatment, in the group taking myo-inositol, both the number and quality of oocytes (immature egg cells) was greatly improved. Large reviews of the scientific literature show uncertainty that inositol improves fertility [ 15, 16].Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial. Inositol is synthesized in the human body, but is also obtained in the diet from foods like citrus fruits, bran, beans, nuts, and seeds. Inositol is a vitamin-like compound found throughout the body, where it plays a significant role in cellular signaling.

Since inositol is involved with neurotransmitter signaling, it could impact mood and feelings of calm. A study published in 2019 concluded that people with PCOS have a two-fold higher risk of developing GD than those without PCOS. Information provided on this web site DOES NOT create a doctor-patient relationship between you and any doctor affiliated with our web site. Brighten contains myo-inositol and d-chiro-inositol in the correct ratio, plus additional ingredients that support optimal blood sugar and hormone health. But independent studies have observed significant issues with product quality and labeling accuracy [ 62].A dosage of 2,000 mg per day of MI and 50 mg of DCI, which is a 40:1 ratio, is generally suggested for PCOS. Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: A perspective, randomized, placebo-controlled study. Voluntary fortification is ineffective to maintain the vitamin B12 and folate status of older Irish adults: evidence from the Irish Longitudinal Study on Ageing (TILDA). Comparison of myo-inositol and metformin on clinical, metabolic and genetic parameters in polycystic ovary syndrome: A randomized controlled clinical trial. Side effects, if any, tend to be mild and may include nausea, stomach pain, tiredness, headache, and dizziness.

Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Increasing the relative amounts of D-chiro inositol above 40:1 appears to reduce effectiveness and may have a negative effect.Taking inositol by mouth seems to lower triglyceride levels, decrease blood pressure, and improve blood sugar, ovulation, and pregnancy rates in people with PCOS. Insulin resistance, a problem with your body’s ability to respond to insulin, is considered one of the key factors associated with conditions like metabolic syndrome ( 8). Uncoupling between insulin and release of a D-chiro-inositol-containing inositol phosphoglycan mediator of insulin action in obese women with polycystic ovary syndrome. One type of diabetes for which the role of inositol has been widely studied is gestational diabetes, a condition characterized by abnormal glucose tolerance and high blood sugar during pregnancy.

In a 2017 review on using inositols in PCOS, and published in Gynecological Endocrinology, the authors found combined treatment with myo-inositol and d-chiro inositol to be effective in restoring ovary function and metabolic balance in PCOS.There are 9 different types of inositol, but the two most studied forms are myo-inositol (MI) and d-chiro-inositol (DCI). The effect of myo-inositol on fertility rates in poor ovarian responder in women undergoing assisted reproductive technique: a randomized clinical trial.