EVO-STIK Plumber's Mait, Non-Setting Putty for Sanitary Joints, Waterproof, 750g

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Gracey, E. et al. IL-7 primes IL-17 in mucosal-associated invariant T (MAIT) cells, which contribute to the Th17-axis in ankylosing spondylitis. Ann. Rheum. Dis. 75, 2124–2132 (2016).

Voillet, V. et al. Human MAIT cells exit peripheral tissues and recirculate via lymph in steady state conditions. JCI Insight 3, e98487 (2018).Turtle, C. J., Swanson, H. M., Fujii, N., Estey, E. H. & Riddell, S. R. A distinct subset of self-renewing human memory CD8 + T cells survives cytotoxic chemotherapy. Immunity 31, 834–844 (2009).

Reantragoon, R. et al. Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells. J. Exp. Med. 210, 2305–2320 (2013). Ref. 20 described the development of MR1-tetramers and defined MAIT cells expressing TRAV1-2 with other TRAJ genes, including TRAJ12 and TRAJ20. Haga, K. et al. MAIT cells are activated and accumulated in the inflamed mucosa of ulcerative colitis. J. Gastroenterol. Hepatol. 31, 965–972 (2016).

Soudais, C. et al. In vitro and in vivo analysis of the Gram-negative bacteria-derived riboflavin precursor derivatives activating mouse MAIT cells. J. Immunol. 194, 4641–4649 (2015). Use the Multi Agency Incident Transfer Version 1.0.0 (MAIT) standard to share electronic incident records if you’re an emergency service. 1. Summary of the standard’s use for government Croxford, J. L., Miyake, S., Huang, Y. Y., Shimamura, M. & Yamamura, T. Invariant V α19i T cells regulate autoimmune inflammation. Nat. Immunol. 7, 987–994 (2006). Cho, Y. N. et al. Mucosal-associated invariant T cell deficiency in systemic lupus erythematosus. J. Immunol. 193, 3891–3901 (2014). Yong, Y. K. et al. Hyper-expression of PD-1 is associated with the levels of exhausted and dysfunctional phenotypes of circulating CD161 ++TCR iVα7.2 + mucosal-associated invariant T cells in chronic hepatitis B virus infection. Front. Immunol. 9, 472 (2018).

Dias, J., Leeansyah, E. & Sandberg, J. K. Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines. Proc. Natl Acad. Sci. USA 114, E5434–E5443 (2017). MAIT cells constitute a subset of αβ T lymphocytes characterized by a semi-invariant T cell receptor alpha (TCRα) chain. The TCRα originates from the rearrangement of TCRα variable (V) and joining (J) gene segments TRAV1-2/TRAJ12/20/33 during VDJ recombination in the nucleus. However, TRAJ33 is expressed more often than TRAJ12 and TRAJ20. [3] [9] With little diversity in the TCRα chain, the TCR is more conserved in MAIT cells than in other T cell subsets. In addition, the TCRα chain can combine with a restricted number of possible TCR β chains to form a functional MAIT cell TCR, further limiting TCR diversity. [10] a b Nel I, Bertrand L, Toubal A, Lehuen A (July 2021). "MAIT cells, guardians of skin and mucosa?". Mucosal Immunology. 14 (4): 803–814. doi: 10.1038/s41385-021-00391-w. PMC 7983967. PMID 33753874. Ebato, M., Nitta, T., Yagita, H., Sato, K. & Okumura, K. Skewed distribution of TCR Vα7-bearing T cells within tumor-infiltrating lymphocytes of HLA-A24(9)-positive patients with malignant glioma. Immunol. Lett. 39, 53–64 (1993). Salou, M. et al. A common transcriptomic program acquired in the thymus defines tissue residency of MAIT and NKT subsets. J. Exp. Med. 216, 133–151 (2019).McWilliam, H. E. et al. The intracellular pathway for the presentation of vitamin B-related antigens by the antigen-presenting molecule MR1. Nat. Immunol. 17, 531–537 (2016).